Neuroendocrine Tumors
These tumors arise from cells that produce various types of hormones. The symptoms experienced by a patient will depend on the specific type of hormone produced.
Hepatocellular Carcinoma (HCC)
This is the most common tumor that develops directly from liver tissue. It is strongly associated with the presence of cirrhosis and chronic viral hepatitis; exposure to certain toxic chemicals may also increase the chances of developing HCC. Patients with early stage HCC are often good candidates for liver transplantation.
Cholangiocarcinoma
This is a relatively rare tumor that arises from cells lining the bile ducts. It occurs more often in patients who also have PSC.
Metabolic and Genetic Disorders
This refers to a group of diseases in which individuals are born lacking the ability to correctly process a specific compound. In general, this will lead to a toxic concentration of the compound in the liver and will result in different degrees of liver damage. As in the case of liver tumors, strict criteria must be met in order for liver transplantation to be a successful treatment. Some of the conditions in this category are listed below.
Alpha 1 Antitrypsin Deficiency
This is a common inherited disorder. A1AT is a protein that helps with the elasticity of the lungs, and it’s predominantly produced in the liver. Having a deficiency of A1AT means that the liver isn’t producing enough of this protein, and it may lead to emphysema, COPD, or other respiratory complications. About 10 to 15% of people with A1AT deficiency also develop liver disease, and a smaller percentage of those will need a liver transplant. Liver transplantation usually returns A1AT production to normal.
Hemochromatosis
People with this disorder absorb an abnormally high amount of iron from their intestines. The liver is a major site of iron storage; in individuals with hemochromatosis, excess iron accumulates in liver cells and often causes the liver to enlarge. However, not all affected people will develop significant liver disease. Additional factors, such as bacterial or viral infections or alcohol consumption are thought to be involved in the progression from iron overload to need for transplantation.
Wilson's Disease
This is an accumulation of copper in the liver, brain, and central nervous system, arising from an inability to properly metabolize the element. It is usually diagnosed in younger individuals (< 30 years) and first treatment is generally with medications that cause the excess copper to be excreted. If drug treatment does not work, liver transplantation will be considered.
Glycogen Storage Disease(s)
This actually refers to several conditions that have in common an inherited inability to correctly process glycogen resulting in abnormal amounts of glycogen in the liver. Normal liver cells produce enzymes needed to deal with some forms of glycogen; therefore, transplantation may be a good therapeutic alternative for selected patients with these deficiencies.
Polycystic Disease
This is an inherited disorder characterized by formation of cysts in kidneys and livers. The cysts in the kidney are usually diagnosed first, although some patients first develop complaints related to liver cysts. Symptoms develop more frequently in female adults and increase with age; the degree of severity varies widely. It is believed that pregnancy or use of hormonal therapy contribute to higher frequency in women. Liver transplantation or combined liver and kidney transplantation in patients who also have significant renal disease are common treatments for those patients who fail to respond to medical management of their disease.
Budd Chiari Syndrome
This syndrome occurs when blood clots form in the large veins that take blood from the liver into general circulation. If the clots are small and do not completely block the flow of blood from the liver, there may be few symptoms and medications to dissolve the clot may be all that is necessary. If the clot is large and completely blocks the blood vessels, blood will back up into the liver and, if not fixed, will cause severe liver damage. In some cases, it may be possible to "re-route" the blood flow by performing an operation. In many cases, liver transplantation will be necessary.